Synthesis and antimicrobial evaluation of some annelated phthalazine derivatives and acyclo C-nucleosides from 1-chloro-4-(2,4,6-trimethylphenyl) phthalazine precursor

Authors

Maher Abdel Aziz El-Hashash
Ahmed Youssef Soliman
Ibrahim Essam ELSHAMY

DOI

10.3906/kim-1111-52

Abstract

A highly efficient and versatile synthetic approach to the synthesis of annelated phthalazine derivatives viz. 1,2,4-triazolo [3,4-a]phthalazine 11a,b, 14, 18, 19a,b, 29-31, 33, 1,2,4-triazino [3,4-a]phthalazine 25a,b-28, 1,3,5-triazino[4,3-a]phthalazine 22, tetrazolo[5,1-a] phthalazine 23, imidazophthalazine 9a,b,15, and pyrimidinophthlazine 6, 10, 16, 17, 20 is presented. Moreover, acyclo C-nucleoside and double headed acyclo C-nucleoside of 1,2,4-triazolo[3,4-a]phthalazine 12, 13 were obtained via heterocyclization reaction of 1-chloro-4-(2,4,6-trimethylphenyl) phthalazine (4) with gluconic acid hydrazide and galactaric acid bis hydrazide, respectively. The new compounds were synthesized with the objective of studying their antimicrobial activity.

Keywords

Triazinophthalazine, pyrazolylphthalazine, triazolophthalazine, antimicrobial activity

First Page

347

Last Page

366

Recommended Citation

El-Hashash, Maher Abdel Aziz; Soliman, Ahmed Youssef; and ELSHAMY, Ibrahim Essam (2012) "Synthesis and antimicrobial evaluation of some annelated phthalazine derivatives and acyclo C-nucleosides from 1-chloro-4-(2,4,6-trimethylphenyl) phthalazine precursor," Turkish Journal of Chemistry: Vol. 36: No. 3, Article 1. https://doi.org/10.3906/kim-1111-52
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss3/1