Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities

Authors

YILDIZ GÜLKOK
TUBA BİÇER
FATMA KAYNAK ONURDAĞ
SELDA ÖZGEN
MUSTAFA FETHİ ŞAHİN
DENİZ SONGÜL DOĞRUER

DOI

10.3906/kim-1106-54

Abstract

In the present study, 18 new compounds were synthesized, 9 of which were urea (9a-e, 10a-d) while the others were thiourea (11a-e, 12a-d) derivatives. These derivatives were prepared by the reaction of 6-amino-5-nonsubstituted/chloro-3-methyl-2(3H)- benzoxazolones used as key intermediates with the appropriate isocyanates and isothiocyanates. The chemical structures of new compounds were confirmed by ^1H-NMR, mass, and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains. Compounds 9a, 9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d, thiourea derivatives, exhibited a relatively good inhibitory profile against E. coli, with a MIC value of 32 \mu g/mL when compared with the other target compounds.

Keywords

Urea, thiourea, 2(3H)-benzoxazolone, antimicrobial activity

First Page

279

Last Page

291

Recommended Citation

GÜLKOK, YILDIZ; BİÇER, TUBA; ONURDAĞ, FATMA KAYNAK; ÖZGEN, SELDA; ŞAHİN, MUSTAFA FETHİ; and DOĞRUER, DENİZ SONGÜL (2012) "Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities," Turkish Journal of Chemistry: Vol. 36: No. 2, Article 7. https://doi.org/10.3906/kim-1106-54
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss2/7