Turkish Journal of Chemistry
Abstract
3-Fluoro-4-(morpholin-4-yl)aniline (2), prepared from 3,4-difluoronitrobenzene, was converted to the corresponding Schiff base (3) by treatment with indol-3-carbaldehyde. The treatment of thiourea 4 and carbothioamide derivatives 9 with ethyl bromoacetate or 4-substituted phenacyl bromides generated the corresponding thiazolidinone (5 and 13) and thiazoline (6 and 12) derivatives, respectively. The acidic or basic treatment of carbothioamide 9 produced 1,3,4-thiadiazole (11) or 1,2,4-triazole (10) compounds, respectively. The structural assignments of the new compounds were based on elemental analysis and spectral (IR, ^1H-NMR, ^{13}C-NMR, and LC-MS) data. The antimicrobial activity study revealed that all compounds showed good antitubercular activities.
DOI
10.3906/kim-1105-54
Keywords
1, 3-Thiazole, 1, 3, 4-thiadiazole, 1, 2, 4-triazole, linezolid, antimicrobial activity
First Page
37
Last Page
53
Recommended Citation
BAŞOĞLU, S, YOLAL, M, DEMİRBAŞ, A, BEKTAŞ, H, ABBASOĞLU, R, & DEMİRBAŞ, N (2012). Synthesis of linezolid-like molecules and evaluation of their antimicrobial activities. Turkish Journal of Chemistry 36 (1): 37-53. https://doi.org/10.3906/kim-1105-54
