Synthesis, characterization, and antimicrobial activity of a new pyrimidine Schiff base and its Cu(II), Ni(II), Co(II), Pt(II), and Pd(II) complexes

Authors

MEHMET GÜLCAN
MEHMET SÖNMEZ
İSMET BERBER

DOI

10.3906/kim-1104-2

Abstract

A new Schiff base, {1-[(5-bromo-2-hydroxy-benzylidene)- amino]-4-phenyl-2-thioxo-1,2-dihyro-pyrimidin-5-yl}-phenyl-methanone, was synthesized from N-amino pyrimidine-2-thione and 5-bromsalicylaldehyde. Metal complexes of the Schiff base were prepared from acetate salts of Cu(II), Ni(II), Co(II), Pd(II), and PtCl_2 in methanol. The chemical structures of the Schiff base ligand and its metal complexes were confirmed by spectroscopic analysis. All of the compounds were evaluated for their antimicrobial against 4 gram-positive bacteria, 1 gram-negative bacterium, and 3 yeast strains. The Schiff base and the Cu(II) and Co(II) complexes showed good biological activity against all tested bacteria and yeast strains.

Keywords

N-aminopyrimidine-2-thione, 5-bromosalicylaldehyde Schiff base, metal complexes, antimicrobial activity

First Page

189

Last Page

200

Recommended Citation

GÜLCAN, MEHMET; SÖNMEZ, MEHMET; and BERBER, İSMET (2012) "Synthesis, characterization, and antimicrobial activity of a new pyrimidine Schiff base and its Cu(II), Ni(II), Co(II), Pt(II), and Pd(II) complexes," Turkish Journal of Chemistry: Vol. 36: No. 1, Article 15. https://doi.org/10.3906/kim-1104-2
Available at: https://journals.tubitak.gov.tr/chem/vol36/iss1/15