Turkish Journal of Chemistry
Abstract
In the present study, some new 2-(pyridin-2-yl)thieno[2,3-d] pyrimidin-4(3H)-ones derivatives (IIa-o) were synthesized. The target compounds (IIa-o) were synthesized through the acid catalyzed condensation of 2-cyano, 3-cyano, and 4-cyano-pyridines with various 2-amino-3-carbethoxythiophenes (Ia-e). All thiophene derivatives were synthesized by Gewald reaction. The structures of the newly synthesized compounds were confirmed by UV-Visible, FT-IR, ^1H-NMR, and mass spectral studies. All synthesized compounds were evaluated for their antimicrobial activity against various gram-positive and gram-negative bacterial and fungal strains. Amongst the synthesized compounds IIa, IIb, IId, IIe, and IIm were found to be active.
DOI
10.3906/kim-1012-888
Keywords
Thienopyrimidine, Gewald reaction, antimicrobial activity
First Page
915
Last Page
924
Recommended Citation
HASWANI, N. G, & BARI, S. B (2011). Synthesis and antimicrobial activity of novel 2-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4 (3H)-ones. Turkish Journal of Chemistry 35 (6): 915-924. https://doi.org/10.3906/kim-1012-888
