Synthesis and antimicrobial activity of novel 2-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4 (3H)-ones

Authors

NITIN G. HASWANI
SANJAYKUMAR B. BARI

DOI

10.3906/kim-1012-888

Abstract

In the present study, some new 2-(pyridin-2-yl)thieno[2,3-d] pyrimidin-4(3H)-ones derivatives (IIa-o) were synthesized. The target compounds (IIa-o) were synthesized through the acid catalyzed condensation of 2-cyano, 3-cyano, and 4-cyano-pyridines with various 2-amino-3-carbethoxythiophenes (Ia-e). All thiophene derivatives were synthesized by Gewald reaction. The structures of the newly synthesized compounds were confirmed by UV-Visible, FT-IR, ^1H-NMR, and mass spectral studies. All synthesized compounds were evaluated for their antimicrobial activity against various gram-positive and gram-negative bacterial and fungal strains. Amongst the synthesized compounds IIa, IIb, IId, IIe, and IIm were found to be active.

Keywords

Thienopyrimidine, Gewald reaction, antimicrobial activity

First Page

915

Last Page

924

Recommended Citation

HASWANI, NITIN G. and BARI, SANJAYKUMAR B. (2011) "Synthesis and antimicrobial activity of novel 2-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4 (3H)-ones," Turkish Journal of Chemistry: Vol. 35: No. 6, Article 9. https://doi.org/10.3906/kim-1012-888
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss6/9