Synthesis, characterization, and biological activity studies of (E)-N'-((thiophen-2-yl)methylene)benzofuran-2-carbohydrazide and its metal(II) complexes

Authors

MADAPPA B. HALLI
VIJAYALAXMI B. PATIL
SUMATHI R. BEVINAMARADA

DOI

10.3906/kim-1008-860

Abstract

Metal complexes of the type MLX_2, where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II), and X = Cl and L = TMBC, Schiff base derived from the condensation of benzofuran-2-carbohydrazide with thiophene-2-aldehyde were synthesized. The structure of the complexes was proposed in light of analytical, IR, UV-Vis, ^1H-NMR, FAB-MS, ESR spectral data, and magnetic studies. The complexes were soluble in DMF and DMSO. The measured molar conductance values indicated that the complexes were nonelectrolytic in nature. On the basis of these studies, 6 coordinated octahedral polymeric structures were assigned to the Co(II), Ni(II), and Cu(II) complexes, and 4 coordinated tetrahedral geometries to the Zn(II), Cd(II), and Hg(II) complexes. The Schiff base and its metal complexes were tested for antibacterial and antifungal activities by the MIC method. The DNA cleavage activities of all of the complexes were studied by the agarose gel electrophoresis method.

Keywords

Benzofuran, Schiff base, metal complexes, spectral studies, antimicrobial activity, DNA cleavage

First Page

393

Last Page

404

Recommended Citation

HALLI, MADAPPA B.; PATIL, VIJAYALAXMI B.; and BEVINAMARADA, SUMATHI R. (2011) "Synthesis, characterization, and biological activity studies of (E)-N'-((thiophen-2-yl)methylene)benzofuran-2-carbohydrazide and its metal(II) complexes," Turkish Journal of Chemistry: Vol. 35: No. 3, Article 4. https://doi.org/10.3906/kim-1008-860
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss3/4