Microwave irradiation, comparable to conventional thermal heating, proves to be a convenient method in assisting the synthesis of some butenamides, pyrrolidine-2,5-diones, and their benzenesulfonamido derivatives, which are known to have biological activities and wide medical and industrial applications. Both procedures were used to compare their efficiency in synthesizing butenamides and pyrrolidine-2,5-diones (2-25), which have important and wide applications, from condensation of \alpha,\beta-unsaturated anhydride (1) with the corresponding amines. Some of the products showed biological or cytotoxic (antiproliferative) activity.
Microwave, butenamides, pyrrolidines, sulfonamides, biological activity, antiproliferative activity
ABDALLAH, SHADIA MAHMOUD and HEFNY, HALIMA ALY
"Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-diones,"
Turkish Journal of Chemistry: Vol. 35:
3, Article 10.
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss3/10