Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-diones

Authors

SHADIA MAHMOUD ABDALLAH
HALIMA ALY HEFNY

DOI

10.3906/kim-1007-807

Abstract

Microwave irradiation, comparable to conventional thermal heating, proves to be a convenient method in assisting the synthesis of some butenamides, pyrrolidine-2,5-diones, and their benzenesulfonamido derivatives, which are known to have biological activities and wide medical and industrial applications. Both procedures were used to compare their efficiency in synthesizing butenamides and pyrrolidine-2,5-diones (2-25), which have important and wide applications, from condensation of \alpha,\beta-unsaturated anhydride (1) with the corresponding amines. Some of the products showed biological or cytotoxic (antiproliferative) activity.

Keywords

Microwave, butenamides, pyrrolidines, sulfonamides, biological activity, antiproliferative activity

First Page

463

Last Page

474

Recommended Citation

ABDALLAH, SHADIA MAHMOUD and HEFNY, HALIMA ALY (2011) "Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-diones," Turkish Journal of Chemistry: Vol. 35: No. 3, Article 10. https://doi.org/10.3906/kim-1007-807
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss3/10