Turkish Journal of Chemistry
Abstract
Microwave irradiation, comparable to conventional thermal heating, proves to be a convenient method in assisting the synthesis of some butenamides, pyrrolidine-2,5-diones, and their benzenesulfonamido derivatives, which are known to have biological activities and wide medical and industrial applications. Both procedures were used to compare their efficiency in synthesizing butenamides and pyrrolidine-2,5-diones (2-25), which have important and wide applications, from condensation of \alpha,\beta-unsaturated anhydride (1) with the corresponding amines. Some of the products showed biological or cytotoxic (antiproliferative) activity.
DOI
10.3906/kim-1007-807
Keywords
Microwave, butenamides, pyrrolidines, sulfonamides, biological activity, antiproliferative activity
First Page
463
Last Page
474
Recommended Citation
ABDALLAH, S. M, & HEFNY, H. A (2011). Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-diones. Turkish Journal of Chemistry 35 (3): 463-474. https://doi.org/10.3906/kim-1007-807
