Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted acetophenone) hydrazone

Authors

SEMRA UTKU
MEHTAP GÖKÇE
GÖNÜL ASLAN
GÜL BAYRAM
MAHMUT ÜLGER
GÜROL EMEKDAŞ
MUSTAFA FETHİ ŞAHİN

DOI

10.3906/kim-1009-63

Abstract

The difficulty in managing tuberculosis includes the prolonged duration of the treatment, the emergence of drug resistance, and coinfection with HIV/AIDS. Tuberculosis control requires new drugs that act on novel drug targets to help in combating resistant forms of Mycobacterium tuberculosis and reduce the treatment duration. For this purpose, 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted/nonsubstituted acetophenone) hydrazone derivatives were synthesized and their structures were elucidated by elemental analyses, IR, and ^1H-NMR. The in vitro antimycobacterial activities of synthesized compounds 5a-l were determined by the agar proportion method against Mycobacterium tuberculosis H37Rv. Among the target compounds, 5b and 5f exhibited the best antimycobacterial activity, with a MIC value of 5 \mu g/mL.

Keywords

3(2H)-Pyridazinone, acetophenone hydrazone, antimycobacterial activity, antitubercular drugs

First Page

331

Last Page

339

Recommended Citation

UTKU, SEMRA; GÖKÇE, MEHTAP; ASLAN, GÖNÜL; BAYRAM, GÜL; ÜLGER, MAHMUT; EMEKDAŞ, GÜROL; and ŞAHİN, MUSTAFA FETHİ (2011) "Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted acetophenone) hydrazone," Turkish Journal of Chemistry: Vol. 35: No. 2, Article 15. https://doi.org/10.3906/kim-1009-63
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss2/15