The difficulty in managing tuberculosis includes the prolonged duration of the treatment, the emergence of drug resistance, and coinfection with HIV/AIDS. Tuberculosis control requires new drugs that act on novel drug targets to help in combating resistant forms of Mycobacterium tuberculosis and reduce the treatment duration. For this purpose, 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted/nonsubstituted acetophenone) hydrazone derivatives were synthesized and their structures were elucidated by elemental analyses, IR, and ^1H-NMR. The in vitro antimycobacterial activities of synthesized compounds 5a-l were determined by the agar proportion method against Mycobacterium tuberculosis H37Rv. Among the target compounds, 5b and 5f exhibited the best antimycobacterial activity, with a MIC value of 5 \mu g/mL.
3(2H)-Pyridazinone, acetophenone hydrazone, antimycobacterial activity, antitubercular drugs
UTKU, SEMRA; GÖKÇE, MEHTAP; ASLAN, GÖNÜL; BAYRAM, GÜL; ÜLGER, MAHMUT; EMEKDAŞ, GÜROL; and ŞAHİN, MUSTAFA FETHİ
"Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted acetophenone) hydrazone,"
Turkish Journal of Chemistry: Vol. 35:
2, Article 15.
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss2/15