Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted acetophenone) hydrazone

Authors

SEMRA UTKU
MEHTAP GÖKÇE
GÖNÜL ASLAN
GÜL BAYRAM
MAHMUT ÜLGER
GÜROL EMEKDAŞ
MUSTAFA FETHİ ŞAHİN

Abstract

The difficulty in managing tuberculosis includes the prolonged duration of the treatment, the emergence of drug resistance, and coinfection with HIV/AIDS. Tuberculosis control requires new drugs that act on novel drug targets to help in combating resistant forms of Mycobacterium tuberculosis and reduce the treatment duration. For this purpose, 6-substituted-3(2H)-pyridazinone-2-acetyl-2- (substituted/nonsubstituted acetophenone) hydrazone derivatives were synthesized and their structures were elucidated by elemental analyses, IR, and ^1H-NMR. The in vitro antimycobacterial activities of synthesized compounds 5a-l were determined by the agar proportion method against Mycobacterium tuberculosis H37Rv. Among the target compounds, 5b and 5f exhibited the best antimycobacterial activity, with a MIC value of 5 \mu g/mL.

DOI

10.3906/kim-1009-63

Keywords

3(2H)-Pyridazinone, acetophenone hydrazone, antimycobacterial activity, antitubercular drugs

First Page

331

Last Page

339

Recommended Citation

UTKU, SEMRA; GÖKÇE, MEHTAP; ASLAN, GÖNÜL; BAYRAM, GÜL; ÜLGER, MAHMUT; EMEKDAŞ, GÜROL; and ŞAHİN, MUSTAFA FETHİ (2011) "Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted acetophenone) hydrazone," Turkish Journal of Chemistry: Vol. 35: No. 2, Article 15. https://doi.org/10.3906/kim-1009-63
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss2/15