A series of [(4-nitro-1H-imidazol-1-yl)methyl]-1,2,4- triazoles and 1,3,4-thiadiazoles were prepared and evaluated for their activity against sensitive and resistant H. pylori strains. Study of the structure-activity relationship of these series of compounds indicated that the type of nitroimidazole moiety and the pendent group on the heteroaryl analog dramatically impact the anti-H. pylori activity. In triazole series, compound 5d, containing a 4-methyl phenyl group on the triazole ring, was the most potent compound tested against both metronidazole-sensitive and -resistant strains at a concentration of 8 \mu g.
FALLAH-TAFTI, ASAL; AKBARZADEH, TAHMINEH; SANIEE, PARASTOO; SIAVOSHI, FARIDEH; SHAFIEE, ABBAS; and FOROUMADI, ALIREZA
"Synthesis and anti-Helicobacter pylori activity of (4-nitro-1-imidazolylmethyl)-1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles,"
Turkish Journal of Chemistry: Vol. 35:
2, Article 13.
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss2/13