Synthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities

Authors

İSMAİL KAYAĞİL
ŞEREF DEMİRAYAK

Abstract

In this study, some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives were synthesized by reacting 1-(2-aryl-2-oxoethyl)-2-aryloyl-4,5-diarylimidazoles from 2-aryloyl-4,5-diarylimidazole and 2-bromoacetophenone derivatives with ammonium acetate in acetic acid by using the method that was previously developed and repeatedly tested in our studies. Structural elucidation of the compounds was performed by IR, ^1H-NMR, and MASS spectroscopic data and elemental analysis results. Anticancer activities of selected compounds were evaluated and the noticeable activity values were reported.

DOI

10.3906/kim-1005-649

Keywords

Substituted imidazoles, imidazo[1, 2-a]pyrazines, microwave irradiation, anticancer activity

First Page

13

Last Page

24

Recommended Citation

KAYAĞİL, İSMAİL and DEMİRAYAK, ŞEREF (2011) "Synthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities," Turkish Journal of Chemistry: Vol. 35: No. 1, Article 2. https://doi.org/10.3906/kim-1005-649
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss1/2