Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).
Isoxazolo[4, 5-d]pyridazin-4(5H)-one, hot-plate test, writhing test, analgesic effect
TAN, OYA ÜNSAL; ÖZADALI, KERİMAN; YEŞİLYURT, ÖZGÜR; KAYIR, HAKAN; UZBAY, İSMAİL TAYFUN; and BALKAN, AYLA
"Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives,"
Turkish Journal of Chemistry: Vol. 35:
1, Article 11.
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss1/11