Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Authors

OYA ÜNSAL TAN
KERİMAN ÖZADALI
ÖZGÜR YEŞİLYURT
HAKAN KAYIR
İSMAİL TAYFUN UZBAY
AYLA BALKAN

DOI

10.3906/kim-1004-584

Abstract

Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).

Keywords

Isoxazolo[4, 5-d]pyridazin-4(5H)-one, hot-plate test, writhing test, analgesic effect

First Page

121

Last Page

130

Recommended Citation

TAN, OYA ÜNSAL; ÖZADALI, KERİMAN; YEŞİLYURT, ÖZGÜR; KAYIR, HAKAN; UZBAY, İSMAİL TAYFUN; and BALKAN, AYLA (2011) "Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives," Turkish Journal of Chemistry: Vol. 35: No. 1, Article 11. https://doi.org/10.3906/kim-1004-584
Available at: https://journals.tubitak.gov.tr/chem/vol35/iss1/11