Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products

Authors

AZIZUDDIN SHAIKH
MUHAMMAD IQBAL CHOUDHARY

DOI

10.3906/kim-0912-400

Abstract

Biotransformation of danazol (17\beta-hydroxy-17\alpha-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17\beta-hydroxy-2-(hydroxymethyl)-17\alpha -pregn-4-en-20-yn-3-one (2) and 17\beta -hydroxy-2-(hydroxymethyl)-17\alpha-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.

Keywords

Biotransformation, danazol, Fusarium solani, Gibberella fujikuorii, prolyl endopeptidase (PEP) inhibition assay

First Page

945

Last Page

952

Recommended Citation

SHAIKH, AZIZUDDIN and CHOUDHARY, MUHAMMAD IQBAL (2010) "Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products," Turkish Journal of Chemistry: Vol. 34: No. 6, Article 11. https://doi.org/10.3906/kim-0912-400
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss6/11