Biotransformation of danazol (17\beta-hydroxy-17\alpha-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17\beta-hydroxy-2-(hydroxymethyl)-17\alpha -pregn-4-en-20-yn-3-one (2) and 17\beta -hydroxy-2-(hydroxymethyl)-17\alpha-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.
Biotransformation, danazol, Fusarium solani, Gibberella fujikuorii, prolyl endopeptidase (PEP) inhibition assay
SHAIKH, AZIZUDDIN and CHOUDHARY, MUHAMMAD IQBAL
"Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products,"
Turkish Journal of Chemistry: Vol. 34:
6, Article 11.
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss6/11