Biotransformation of danazol (17\beta-hydroxy-17\alpha-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17\beta-hydroxy-2-(hydroxymethyl)-17\alpha -pregn-4-en-20-yn-3-one (2) and 17\beta -hydroxy-2-(hydroxymethyl)-17\alpha-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.
SHAIKH, AZIZUDDIN and CHOUDHARY, MUHAMMAD IQBAL
"Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products,"
Turkish Journal of Chemistry: Vol. 34:
6, Article 11.
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss6/11