An efficient green protocol is described for the preparation of \alpha -amino phosphonates, employing a one-pot three-component condensation reaction between aldehydes, amines, and trialkyl phosphites in the presence of PPA-SiO_2 under solvent-free conditions at 80 °C. The present procedure offer advantages such as high to excellent yields, short reaction time, inexpensiveness, recovery, and reusability of catalyst.
MAGHSOODLOU, MALEK TAHER; HABIBI-KHORASSANI, SAYYED MOSTAFA; HEYDARI, REZA; HAZERI, NOUROLLAH; SAJADIKHAH, SEYED SAJAD; ROSTAMIZADEH, MOHSEN; and KEISHAMS, LEILA
"Silica supported polyphosphoric acid (PPA-SiO_2): an efficient and reusable heterogeneous catalyst for the one-pot synthesis of \alpha -amino phosphonates,"
Turkish Journal of Chemistry: Vol. 34:
4, Article 8.
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss4/8