Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles

Authors

MELTEM ÇETİN
İMRAN VURAL
ALPTUĞ ATİLA
YÜCEL KADIOĞLU

DOI

10.3906/kim-0910-237

Abstract

This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-co-glycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was performed by using Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOX-loaded PLGA microparticles had an average diameter of 500 \pm 9 nm. The DOX encapsulation efficiency and drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant cytotoxicity toward the RG2 cells as compared to the unloaded PLGA

First Page

509

Last Page

516

Recommended Citation

ÇETİN, MELTEM; VURAL, İMRAN; ATİLA, ALPTUĞ; and KADIOĞLU, YÜCEL (2010) "Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles," Turkish Journal of Chemistry: Vol. 34: No. 4, Article 3. https://doi.org/10.3906/kim-0910-237
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss4/3