Some new unsymmetrical and optically active 2,5-disubstituted 1,3,4-oxadiazoles 5a-j were efficiently synthesized by cyclization reaction of diacylhydrazides 4a-j. The synthesis of the title compounds was achieved by the reaction of acyl hydrazides 3a-b and N-phetaloyl-L-amino acids 1a-e in the presence of the phosphoroxy chloride (POCl_3) as an anhydrous reagent.
N-phetaloyl-L-amino acid, 1, 3, 4-oxadiazole, diacylhydrazide, pyridoyl hydrazide, phosphoroxy chloride
FOROUGHIFAR, NASER; MOBINIKHALEDI, AKBAR; and EBRAHIMI, SATTAR
"A simple and efficient procedure for synthesis of optically active 1,3,4-oxadiazole derivatives containing L-amino acid moieties,"
Turkish Journal of Chemistry: Vol. 34:
4, Article 12.
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss4/12