A simple and efficient procedure for synthesis of optically active 1,3,4-oxadiazole derivatives containing L-amino acid moieties

Authors

NASER FOROUGHIFAR
AKBAR MOBINIKHALEDI
SATTAR EBRAHIMI

DOI

10.3906/kim-0906-60

Abstract

Some new unsymmetrical and optically active 2,5-disubstituted 1,3,4-oxadiazoles 5a-j were efficiently synthesized by cyclization reaction of diacylhydrazides 4a-j. The synthesis of the title compounds was achieved by the reaction of acyl hydrazides 3a-b and N-phetaloyl-L-amino acids 1a-e in the presence of the phosphoroxy chloride (POCl_3) as an anhydrous reagent.

Keywords

N-phetaloyl-L-amino acid, 1, 3, 4-oxadiazole, diacylhydrazide, pyridoyl hydrazide, phosphoroxy chloride

First Page

603

Last Page

611

Recommended Citation

FOROUGHIFAR, NASER; MOBINIKHALEDI, AKBAR; and EBRAHIMI, SATTAR (2010) "A simple and efficient procedure for synthesis of optically active 1,3,4-oxadiazole derivatives containing L-amino acid moieties," Turkish Journal of Chemistry: Vol. 34: No. 4, Article 12. https://doi.org/10.3906/kim-0906-60
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss4/12