Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureasreas

Authors

AAMER SAEED
RASHEED AHMAD KHERA
NAEEM ABBAS
MUHAMMAD LATIF
IMRAN SAJID
ULRICH FLÖRKE

DOI

10.3906/kim-0810-44

Abstract

Synthesis of some novel 1-(3,4,5-trimethoxy)benzoyl-3- arylthiourea derivatives (1a-o) was accomplished in 2 steps. The synthetic route involves the reaction of 1-(3,4,5-trimethoxy)benzoyl chloride with potassium thiocyanate in 1:1 molar ratio in acetone to afford the corresponding isothiocyante followed by treatment with suitably substituted anilines. The structures of the products were established by elemental analyses, IR, ^1H- and ^{13}C-NMR, and mass spectroscopy and for 1b and 1m from single crystal X-ray diffraction data. All of the synthesized compounds (1a-o) were screened for antibacterial activity against gram positive and gram negative bacterial strains and were found to exhibit low activity towards the tested microorganisms, compared to chloramphenicol, the standard drug.

Keywords

1-(3, 4, 5-trimethoxy)benzoyl-3-arylthioureas, antibacterial, crystal structure.

First Page

335

Last Page

346

Recommended Citation

SAEED, AAMER; KHERA, RASHEED AHMAD; ABBAS, NAEEM; LATIF, MUHAMMAD; SAJID, IMRAN; and FLÖRKE, ULRICH (2010) "Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureasreas," Turkish Journal of Chemistry: Vol. 34: No. 3, Article 2. https://doi.org/10.3906/kim-0810-44
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss3/2