Synthesis, characterization, antibacterial and antifungal evaluation of some new platinum(II) complexes of 2-phenylbenzimidazole ligands

Authors

SEMRA UTKU
MUSTAFA TOPAL
AYLİN DÖĞEN
MEHMET SAMİ SERİN

DOI

10.3906/kim-1002-5

Abstract

A series of platinum(II) complexes of the type [PtL_2Cl_2] 1, [PtL_2I_2] 2, [PtL_2(oxalato)] 3, and [PtL_2(malonato)] 4 (L= 2-phenylbenzimidazole ligands as ``non-leaving groups'') were synthesized and characterized by their elemental analyses, IR, ^1H NMR, and ESI-LC/MS. The in vitro antimicrobial activity of the synthesized compounds has been evaluated by the macrodilution method against gram-positive bacteria, such as Staphylococcus aureus, Bacillus subtilis, and Enterococcus faecalis; gram-negative bacteria, such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia; and yeast like fungi, such as Candida glabrata and Candida parapsilosis. In general, based on the data obtained in this study, synthesized complexes 1-4 might be taken into consideration as promising antifungal compounds.

Keywords

Antibacterial activity, antifungal activity, benzimidazole, carboxylato complexes, platinum(II) complexes.

First Page

427

Last Page

436

Recommended Citation

UTKU, SEMRA; TOPAL, MUSTAFA; DÖĞEN, AYLİN; and SERİN, MEHMET SAMİ (2010) "Synthesis, characterization, antibacterial and antifungal evaluation of some new platinum(II) complexes of 2-phenylbenzimidazole ligands," Turkish Journal of Chemistry: Vol. 34: No. 3, Article 12. https://doi.org/10.3906/kim-1002-5
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss3/12