Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Authors

DENİZ S. DOĞRUER
ŞÖLEN URLU
TİJEN ÖNKOL
BERRİN ÖZÇELİK
M. FETHİ ŞAHİN

Abstract

Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by ^1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 \mu g/mL) and E. coli (MIC ranging from 4 to 16 \mu g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 \mu g/mL.

DOI

10.3906/kim-0904-27

Keywords

Pyridazine derivatives, antibacterial activity, antifungal activity.

First Page

57

Last Page

65

Recommended Citation

DOĞRUER, DENİZ S.; URLU, ŞÖLEN; ÖNKOL, TİJEN; ÖZÇELİK, BERRİN; and ŞAHİN, M. FETHİ (2010) "Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity," Turkish Journal of Chemistry: Vol. 34: No. 1, Article 6. https://doi.org/10.3906/kim-0904-27
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss1/6