Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Authors

DENİZ S. DOĞRUER
ŞÖLEN URLU
TİJEN ÖNKOL
BERRİN ÖZÇELİK
M. FETHİ ŞAHİN

DOI

10.3906/kim-0904-27

Abstract

Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by ^1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 \mu g/mL) and E. coli (MIC ranging from 4 to 16 \mu g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 \mu g/mL.

Keywords

Pyridazine derivatives, antibacterial activity, antifungal activity.

First Page

57

Last Page

65

Recommended Citation

DOĞRUER, DENİZ S.; URLU, ŞÖLEN; ÖNKOL, TİJEN; ÖZÇELİK, BERRİN; and ŞAHİN, M. FETHİ (2010) "Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity," Turkish Journal of Chemistry: Vol. 34: No. 1, Article 6. https://doi.org/10.3906/kim-0904-27
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss1/6