Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode

Authors

MAHLA TABESHNIA
HOSSEIN HELI
ALI JABBARI
ALI A. MOOSAVI-MOVAHEDI

DOI

10.3906/kim-0810-9

Abstract

The electro-oxidation of mefenamic acid, diclofenac, and indomethacin on glassy carbon and alumina nanoparticle-modified glassy carbon electrodes in a phosphate buffer solution at physiological pH was studied. The techniques of cyclic voltammetry, chronoamperometry, impedance spectroscopy, and steady state polarization measurements were applied. The drugs were irreversibly oxidized on bath electrodes via an anodic peak and the process was controlled by diffusion in the bulk of solution. Alumina nanoparticles increased the oxidation current, and lowered the peak and onset potentials. As such, alumina nanoparticles had an electrocatalytic effect, both kinetically and thermodynamically. The kinetic parameters of heterogeneous electron transfer and diffusion coefficients of the drugs are reported.

Keywords

Modified electrode; alumina nanoparticle; electrocatalysis; mefenamic acid, diclofenac, indomethacin.

First Page

35

Last Page

46

Recommended Citation

TABESHNIA, MAHLA; HELI, HOSSEIN; JABBARI, ALI; and MOOSAVI-MOVAHEDI, ALI A. (2010) "Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode," Turkish Journal of Chemistry: Vol. 34: No. 1, Article 4. https://doi.org/10.3906/kim-0810-9
Available at: https://journals.tubitak.gov.tr/chem/vol34/iss1/4