An efficient one pot synthesis of 1,4-dihydropyridines using alumina sulfuric acid (ASA) catalyst

Authors

MUSTAFA ARSLAN
CÜNEYT FAYDALI
MUSTAFA ZENGİN
MUSTAFA KÜÇÜKİSLAMOĞLU
HÜLYA DEMİRHAN

Abstract

An efficient synthetic method for 1,4-dihydropyridines has been developed using 3 or 4 component condensation reactions of aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate in the presence of alumina sulfuric acid catalyst in minimum methanol at reflux temperature. This procedure offers several advantages including high yields, an environmentally friendly procedure, short reaction times, and a simple work-up procedure.

DOI

10.3906/kim-0812-5

Keywords

Hantzsch, 1, 4-dihydropyridines, ASA catalyst, one pot conversion.

First Page

769

Last Page

774

Recommended Citation

ARSLAN, MUSTAFA; FAYDALI, CÜNEYT; ZENGİN, MUSTAFA; KÜÇÜKİSLAMOĞLU, MUSTAFA; and DEMİRHAN, HÜLYA (2009) "An efficient one pot synthesis of 1,4-dihydropyridines using alumina sulfuric acid (ASA) catalyst," Turkish Journal of Chemistry: Vol. 33: No. 6, Article 5. https://doi.org/10.3906/kim-0812-5
Available at: https://journals.tubitak.gov.tr/chem/vol33/iss6/5