A series of 9 new (E)-thiazachalcones (1-3), and their N-alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds (1-3) were calculated theoretically. Experimental and theoretical calculation showed that \delta-truxinic type dimer is the most stable isomer.
Thiazachalcones, N-decyl-4-thiazaclaconium bromide, photodimerization, antimicrobial activity.
USTA, ASU; YAŞAR, AHMET; YAYLI, NURAN; KARAOĞLU, ŞENGÜL ALPAY; and YAYLI, NURETTİN
"Synthesis of methyl (E)-2',4''-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities,"
Turkish Journal of Chemistry: Vol. 33:
5, Article 6.
Available at: https://journals.tubitak.gov.tr/chem/vol33/iss5/6