Synthesis and evaluation of phenytoin derivatives as anticonvulsant agents

Authors

MEENAKSHI DEODHAR
PRAVIN SABLE
ASHOK BHOSALE
KAPIL JUVALE
RAHUL DUMBARE
PRAMOD SAKPAL

DOI

10.3906/kim-0711-18

Abstract

2,5-Dioxo-4,4-diphenylimidazolidine-1-carboxylic acid (2) was reacted with methyl ester of different amino acids (1a-c) and substituted benzhydrols (3a-b) in pyridine and in the presence of N,N dicyclohexyl carbodiimide (DCC) to yield a series of the title compounds, methyl 2-(2,5-dioxo-4,4-diphenylimidazolidine-1-carboxamido) substituted propanoate (4a-c) and benzhydryl 2,5-dioxo-4,4-diphenyl imidazolidine-1-carboxylate (5a-b). The structures of these compounds were established on the basis of their spectral (IR, ^1H-NMR) data. These newly synthesized derivatives of phenytoin were evaluated in terms of anticonvulsant activity.

Keywords

Phenytoin, hydantoin, anticonvulsant activity.

First Page

367

Last Page

373

Recommended Citation

DEODHAR, MEENAKSHI; SABLE, PRAVIN; BHOSALE, ASHOK; JUVALE, KAPIL; DUMBARE, RAHUL; and SAKPAL, PRAMOD (2009) "Synthesis and evaluation of phenytoin derivatives as anticonvulsant agents," Turkish Journal of Chemistry: Vol. 33: No. 3, Article 6. https://doi.org/10.3906/kim-0711-18
Available at: https://journals.tubitak.gov.tr/chem/vol33/iss3/6