2,5-Dioxo-4,4-diphenylimidazolidine-1-carboxylic acid (2) was reacted with methyl ester of different amino acids (1a-c) and substituted benzhydrols (3a-b) in pyridine and in the presence of N,N dicyclohexyl carbodiimide (DCC) to yield a series of the title compounds, methyl 2-(2,5-dioxo-4,4-diphenylimidazolidine-1-carboxamido) substituted propanoate (4a-c) and benzhydryl 2,5-dioxo-4,4-diphenyl imidazolidine-1-carboxylate (5a-b). The structures of these compounds were established on the basis of their spectral (IR, ^1H-NMR) data. These newly synthesized derivatives of phenytoin were evaluated in terms of anticonvulsant activity.
Phenytoin, hydantoin, anticonvulsant activity.
DEODHAR, MEENAKSHI; SABLE, PRAVIN; BHOSALE, ASHOK; JUVALE, KAPIL; DUMBARE, RAHUL; and SAKPAL, PRAMOD
"Synthesis and evaluation of phenytoin derivatives as anticonvulsant agents,"
Turkish Journal of Chemistry: Vol. 33:
3, Article 6.
Available at: https://journals.tubitak.gov.tr/chem/vol33/iss3/6