Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

Authors

ABD EL-GALIL E. AMR
NAGLAA A. ABDEL-HAFEZ
SALWA F. MOHAMED
MOHAMED M. ABDALLA

DOI

10.3906/kim-0811-16

Abstract

We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD_{50}. The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide^{\textregistered} and Lidocaine^{\textregistered} as positive antiarrhythmic controls.

Keywords

Pyrimidine, pyrimidinethione, thiazolopyrimidine, antiarrhythmic activity.

First Page

421

Last Page

432

Recommended Citation

AMR, ABD EL-GALIL E.; ABDEL-HAFEZ, NAGLAA A.; MOHAMED, SALWA F.; and ABDALLA, MOHAMED M. (2009) "Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety," Turkish Journal of Chemistry: Vol. 33: No. 3, Article 12. https://doi.org/10.3906/kim-0811-16
Available at: https://journals.tubitak.gov.tr/chem/vol33/iss3/12