Turkish Journal of Chemistry
Abstract
We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD_{50}. The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide^{\textregistered} and Lidocaine^{\textregistered} as positive antiarrhythmic controls.
DOI
10.3906/kim-0811-16
Keywords
Pyrimidine, pyrimidinethione, thiazolopyrimidine, antiarrhythmic activity.
First Page
421
Last Page
432
Recommended Citation
AMR, A. E, ABDEL-HAFEZ, N. A, MOHAMED, S. F, & ABDALLA, M. M (2009). Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety. Turkish Journal of Chemistry 33 (3): 421-432. https://doi.org/10.3906/kim-0811-16
