A Mild Method for the Cleavage of Ketals Using IBX

Authors

ABDUL RAUF RAZA

Abstract

Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.

DOI

10.3906/kim-0810-50

Keywords

Deprotection, ketal, IBX, ketone, single electron transfer, batrachotoxin.

First Page

209

Last Page

214

Recommended Citation

RAZA, ABDUL RAUF (2009) "A Mild Method for the Cleavage of Ketals Using IBX," Turkish Journal of Chemistry: Vol. 33: No. 2, Article 3. https://doi.org/10.3906/kim-0810-50
Available at: https://journals.tubitak.gov.tr/chem/vol33/iss2/3