Production of (S)-(-)-1-(1´-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone

Authors

ESABİ BAŞARAN KURBANOĞLU
KANİ ZİLBEYAZ
NAMUDAR I. KURBANOĞLU
MESUT TAŞKIN
HAMDULLAH KILIÇ

DOI

-

Abstract

The bioreduction of 1-acetonaphthone 1 by locally isolated Rhodotorula glutinis strains using ram horn peptone (RHP) gave (S)-(-)-1-(1´-naphthyl) ethanol (2), an important pharmaceutical intermediate. R. glutinis strains were isolated from the water of fermented Salix leaves. Optimum fermentation conditions for the production of 2 were 200 rpm, 32 °C, and pH 6.5. The production of 2 with excellent enantiomeric excess (>99%), and good conversion (100%) and yield (78%) under optimum conditions was achieved up to preparative scale via a fermenter. Wide temperature, pH, time, and agitation ranges did not affect the enantiomeric excess (ee) of the bioreduction product. A simple process for the isolation of R. glutinis was also developed.

Keywords

Acetonapthone; bioreduction; microbial reduction; asymmetric reduction.

First Page

685

Last Page

692

Recommended Citation

KURBANOĞLU, ESABİ BAŞARAN; ZİLBEYAZ, KANİ; KURBANOĞLU, NAMUDAR I.; TAŞKIN, MESUT; and KILIÇ, HAMDULLAH (2008) "Production of (S)-(-)-1-(1´-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone," Turkish Journal of Chemistry: Vol. 32: No. 6, Article 4. Available at: https://journals.tubitak.gov.tr/chem/vol32/iss6/4