Turkish Journal of Chemistry
DOI
-
Abstract
Fourteen new 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]- 3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and appropriate sodium salts of N,N-disubstituted dithiocarbamoic acids in acetone. The structures of the synthesized compounds were confirmed by UV, IR, ^1H-NMR, and FAB^+-MS spectral data. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results showed that all of the tested compounds were inactive against the test organism.
Keywords
2-Pyrazolines, Sodium salts of N, N-disubstituted dithiocarbamoic acids, Antimycobacterial activity.
First Page
529
Last Page
538
Recommended Citation
ÖZDEMİR, AHMET; ZITOUNI, GÜLHAN TURAN; and KAPLANCIKLI, ZAFER ASIM (2008) "Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation," Turkish Journal of Chemistry: Vol. 32: No. 5, Article 2. Available at: https://journals.tubitak.gov.tr/chem/vol32/iss5/2
