Synthesis and Antimicrobial Activity of Some 3(2H)-Pyridazinone and 1(2H)-Phthalazinone Derivatives

Authors

DENİZ S. DOĞRUER
TİJEN ÖNKOL
SEMİHA ÖZKAN
SELDA ÖZGEN
M. FETHİ ŞAHİN

DOI

-

Abstract

Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized. The structures of these new compounds were confirmed by IR, ^1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria and their clinical isolates and for their antimycobacterial activity against M. tuberculosis H37Rv. The results showed that the synthesized compounds were generally active against B. subtilis and its clinical isolate. Among the target compounds, compound 14c exhibited the best antibacterial activity, with a MIC value of 15.62 \mu g/mL against B. subtilis. Compound 15e had the highest antimycobacterial activity.

Keywords

3(2H)-pyridazinone, 1(2H)-phthalazinone, antimicrobial activity

First Page

469

Last Page

479

Recommended Citation

DOĞRUER, DENİZ S.; ÖNKOL, TİJEN; ÖZKAN, SEMİHA; ÖZGEN, SELDA; and ŞAHİN, M. FETHİ (2008) "Synthesis and Antimicrobial Activity of Some 3(2H)-Pyridazinone and 1(2H)-Phthalazinone Derivatives," Turkish Journal of Chemistry: Vol. 32: No. 4, Article 7. Available at: https://journals.tubitak.gov.tr/chem/vol32/iss4/7