An Electrochemical DNA Biosensor for the Detection of DNA Damage Caused by Radioactive Iodine and Technetium

Authors

PINAR KARA
KAĞAN DAĞDEVİREN
MEHMET ÖZSÖZ

DOI

-

Abstract

A DNA damage process by radioactive iodine (I-131) and technetium (Tc-99m) is described. The procedure relies on a label-free electrochemical DNA biosensor. Fish sperm double stranded DNA was immobilized onto a carbon paste electrode (CPE) by electro deposition and the changes to the guanine oxidation signal were observed upon exposure to radioactive I-131 and Tc-99m by differential pulse voltammetry (DPV). The changes to the signal of guanine after exposure to therapeutic doses of Tc-99m and I-131 showed conformational changes in DNA molecules.

Keywords

Electrochemistry, DNA damage, Tc-99m, iodine-131

First Page

243

Last Page

249

Recommended Citation

KARA, PINAR; DAĞDEVİREN, KAĞAN; and ÖZSÖZ, MEHMET (2007) "An Electrochemical DNA Biosensor for the Detection of DNA Damage Caused by Radioactive Iodine and Technetium," Turkish Journal of Chemistry: Vol. 31: No. 3, Article 1. Available at: https://journals.tubitak.gov.tr/chem/vol31/iss3/1