A chemoenzymatic synthesis of 2-bromo-6-hydroxy-3-methoxy-2- cyclohexen-1-one starting from cyclohexane-1,3-dione is reported. Manganese(III) acetate-mediated acetoxylation followed by the enzyme-mediated hydrolysis of \alpha'-acetoxy enone affords hydroxy-enone 5 and acetoxy enone 4 with high enantiomeric excesses in good yields.
Chemoenzymatic synthesis, cyclic polyoxo cyclohexenones, manganese(III) acetate, acetoxylation
KARAASLAN, EMİNE ÖZGÜL and TOKA, YASEMİN (2007) "Chemoenzymatic Synthesis of 2-Bromo-6-Hydroxy-3-Methoxy-2-Cyclohexen-1-one," Turkish Journal of Chemistry: Vol. 31: No. 2, Article 5. Available at: https://journals.tubitak.gov.tr/chem/vol31/iss2/5