A quick and convenient method for the preparation of 2-aminobenzophenone derivatives is described. This approach consists of the nucleophilic substitution reaction of nitrobenzenes by phenylacetonitrile under conventional and ultrasonic conditions followed by reduction of the produced 2,1-benzisoxazole to 2-aminobenzophenone. This 2-step reaction was studied by changing the reaction parameters (reaction temperature, ultrasound power, and reaction time). The results clearly demonstrated that using ultrasound irradiation results in a high yield within a short reaction time.
SAFAEI-GHOMI, JAVAD; FADAEIAN, MANOUCHEHR; and HATAMI, ALIREZA (2007) "A Convenient Method for the Preparation of 2-Aminobenzophenone Derivatives under Ultrasonic Irradiation," Turkish Journal of Chemistry: Vol. 31: No. 1, Article 11. Available at: https://journals.tubitak.gov.tr/chem/vol31/iss1/11