Turkish Journal of Chemistry
Abstract
The thiophene analogue of (\pm)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisation of the triple bond. The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.
DOI
-
Keywords
Sonogashira reaction, 4-ipomeanol, cytotoxic activity, MTT assay
First Page
451
Last Page
454
Recommended Citation
KRAUSS, JURGEN; UNTERREITMEIER, DORIS; and BRACHER, FRANZ (2006) "Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation," Turkish Journal of Chemistry: Vol. 30: No. 4, Article 5. Available at: https://journals.tubitak.gov.tr/chem/vol30/iss4/5
