Turkish Journal of Chemistry

Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation

JURGEN KRAUSS
DORIS UNTERREITMEIER
FRANZ BRACHER

Abstract

The thiophene analogue of (\pm)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisation of the triple bond. The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.

DOI

Keywords

Sonogashira reaction, 4-ipomeanol, cytotoxic activity, MTT assay

First Page

451

Last Page

454

Recommended Citation

KRAUSS, J, UNTERREITMEIER, D, & BRACHER, F (2006). Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation. Turkish Journal of Chemistry 30 (4): 451-454. https://doi.org/-

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