Turkish Journal of Chemistry
DOI
-
Abstract
The thiophene analogue of (\pm)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisation of the triple bond. The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.
Keywords
Sonogashira reaction, 4-ipomeanol, cytotoxic activity, MTT assay
First Page
451
Last Page
454
Recommended Citation
KRAUSS, JURGEN; UNTERREITMEIER, DORIS; and BRACHER, FRANZ (2006) "Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation," Turkish Journal of Chemistry: Vol. 30: No. 4, Article 5. Available at: https://journals.tubitak.gov.tr/chem/vol30/iss4/5
