Organotin (IV) Derivatives of 1-Ethyl-1,4-Dihydro-7-Methyl-4-Oxo- 1,8-Naphthyridine-3-Carboxylic Acid (Nalidixic Acid): Synthesis, Structural Elucidation and Biological Activities

Authors

SAJJAD AHMED
MOAZZAM HUSSAIN BHATTI
SAQIB ALI
FIAZ AHMED

DOI

-

Abstract

Organotin carboxylates of the general formulae R_2SnL_2 and R_3SnL, where R = CH_3, n-C_4H_9, C_6H_5, CH_2C_6H_5 and L = 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (nalidixic acid), have been prepared. These compounds were characterized by FT-IR, mass and multinuclear NMR (^1H, ^{13}C and ^{119}Sn) spectroscopy. The geometry around the tin atom is compared both in solution and in solid state. These compounds were also screened for their antifungal and antibacterial activities.

Keywords

Organotin(IV) complexes, 1-ethyl-1, 4-dihydro-7-methyl-4-oxo-1, 8- naphthyridine-3-carboxylic acid (nalidixic acid), Spectroscopic characterization, Biological Activity

First Page

193

Last Page

202

Recommended Citation

AHMED, SAJJAD; BHATTI, MOAZZAM HUSSAIN; ALI, SAQIB; and AHMED, FIAZ (2006) "Organotin (IV) Derivatives of 1-Ethyl-1,4-Dihydro-7-Methyl-4-Oxo- 1,8-Naphthyridine-3-Carboxylic Acid (Nalidixic Acid): Synthesis, Structural Elucidation and Biological Activities," Turkish Journal of Chemistry: Vol. 30: No. 2, Article 7. Available at: https://journals.tubitak.gov.tr/chem/vol30/iss2/7