A New Approach Towards (\pm)-4-Ipomeanol and Its 2-Furyl Regioisomer

Authors

JURGEN KRAUSS
FRANZ BRACHER
DORIS UNTERREITMEIER

DOI

-

Abstract

The cytotoxic furan derivative (\pm)-4-ipomeanol (1) and its regioisomer (8) were prepared in a new and efficient way starting from commercially available furan derivatives. In both cases the key step was a regioselective solvolysis of the terminal double bond with trifluoroacetic anhydride and boron trifluoride. The resulting compounds were tested in an agar diffusion assay against several bacteria and fungi, but did not show significant activity.

Keywords

(\pm)-4-ipomeanol, solvolysis, antimicrobial activity

First Page

635

Last Page

640

Recommended Citation

KRAUSS, JURGEN; BRACHER, FRANZ; and UNTERREITMEIER, DORIS (2005) "A New Approach Towards (\pm)-4-Ipomeanol and Its 2-Furyl Regioisomer," Turkish Journal of Chemistry: Vol. 29: No. 6, Article 7. Available at: https://journals.tubitak.gov.tr/chem/vol29/iss6/7