Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl- benzimidazoles were synthesized and characterized by elemental analysis, and IR and ^1H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.
Benzimidazol, Platinum(II) complexes, In vitro genotoxic activity, Rec-Assay test
ALGÜL, ÖZTEKİN; ÖZÇELİK, BERRİN; ABBASOĞLU, UFUK; and GÜMÜŞ, FATMA (2005) "Synthesis, Characterization and Genotoxicity of Platinum(II)Complexes With Subtituted Benzimidazole Ligands," Turkish Journal of Chemistry: Vol. 29: No. 6, Article 4. Available at: https://journals.tubitak.gov.tr/chem/vol29/iss6/4