Synthesis, Characterization and Genotoxicity of Platinum(II)Complexes With Subtituted Benzimidazole Ligands

Authors

ÖZTEKİN ALGÜL
BERRİN ÖZÇELİK
UFUK ABBASOĞLU
FATMA GÜMÜŞ

DOI

-

Abstract

Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl- benzimidazoles were synthesized and characterized by elemental analysis, and IR and ^1H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.

Keywords

Benzimidazol, Platinum(II) complexes, In vitro genotoxic activity, Rec-Assay test

First Page

607

Last Page

615

Recommended Citation

ALGÜL, ÖZTEKİN; ÖZÇELİK, BERRİN; ABBASOĞLU, UFUK; and GÜMÜŞ, FATMA (2005) "Synthesis, Characterization and Genotoxicity of Platinum(II)Complexes With Subtituted Benzimidazole Ligands," Turkish Journal of Chemistry: Vol. 29: No. 6, Article 4. Available at: https://journals.tubitak.gov.tr/chem/vol29/iss6/4