Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications

Authors

SAIRA SHAHZADI
KHADIJA SHAHID
SAQIB ALI
MOHAMMAD MAZHAR
AMIN BADSHAH
EJAZ AHMED
ABDUL MALIK

DOI

-

Abstract

Some new di- and tri-organotin(IV) derivatives of 4 different non-steroidal anti-inflammatory drugs (NSAIDs) with the general formulae R_2SnL_2 and R_3SnL (where R = n-C_{8}H_{17} and C_6H_5CH_2) and L = 2-[(2,3-dimethylphenyl)amino]benzoic acid, 2-(2-fluoro-4-biphenyl)propionic acid, 2-(4-isobutylphenyl) propionic acid and 2-(3-benzoylphenyl)-propionic acid were synthesized. These compounds were structurally characterized by infrared and multinuclear NMR (^1H, ^{13}C, ^{119}Sn) spectroscopies and mass spectrometry. The isotopic effect of tin was studied by comparison of experimental data with the simulated isotopic pattern using the Chemtool software package. These compounds were also screened against different animal and plant pathogens to study their biological activity. LD_{50} data show that the reported compounds have significant toxicity.

First Page

273

Last Page

288

Recommended Citation

SHAHZADI, SAIRA; SHAHID, KHADIJA; ALI, SAQIB; MAZHAR, MOHAMMAD; BADSHAH, AMIN; AHMED, EJAZ; and MALIK, ABDUL (2005) "Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications," Turkish Journal of Chemistry: Vol. 29: No. 3, Article 7. Available at: https://journals.tubitak.gov.tr/chem/vol29/iss3/7