Synthesis, Characterization and Primary Antimicrobial Activity Evaluation of 3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic Acid Arylidenehydrazides

Authors

AYSEL GÜRSOY
BANU ÜNAL
NİLGÜN KARALI
GÜLTEN ÖTÜK

DOI

-

Abstract

3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic acid hydrazide (3) was reacted with substituted aldehydes in absolute ethanol to obtain a new series, 3-phenyl-6-methyl-4(3H)-quinazolinone- 2-yl-mercaptoacetic acid arylidenehydrazides (4a-q). The structures of 4a-q were elucidated by elemental analyses and from spectrometric (UV, IR, ^1H-NMR, ^{13}C-NMR and EIMS) data. Then 4a-q were evaluated for antibacterial, antifungal and antitubercular activities. No significant activity was observed against the selected microorganisms.

Keywords

4(3H)-Quinazolinone, arylidenehydrazide, synthesis, antimicrobial activity.

First Page

233

Last Page

246

Recommended Citation

GÜRSOY, AYSEL; ÜNAL, BANU; KARALI, NİLGÜN; and ÖTÜK, GÜLTEN (2005) "Synthesis, Characterization and Primary Antimicrobial Activity Evaluation of 3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic Acid Arylidenehydrazides," Turkish Journal of Chemistry: Vol. 29: No. 3, Article 3. Available at: https://journals.tubitak.gov.tr/chem/vol29/iss3/3