Turkish Journal of Chemistry
Abstract
3-Dihalophenyl- and dihalobenzylisocoumarins (3a-c) were synthesized by condensation of homophthalic acid (1) with dihalobenzoyl- and dihalophenylacetyl chlorides (2a-c), respectively. The alkaline hydrolysis of these isocoumarins (2a-c) afforded keto-acids (4a-c). (dl)-3-(Dihalophenyl)- and (dl)-3-(dihalobenzyl)- 3,4-dihydroisocoumarins (6a-c) were obtained by reduction of keto-acids (4a-c) to racemic hydroxy-acids (5a-c) followed by cyclodehydration using acetic anhydride.
DOI
-
Keywords
Dihaloisocoumarins, Dihydrodihaloisocoumarins, synthesis.
First Page
321
Last Page
326
Recommended Citation
SHAFIQ, Z, ARFAN, M, RAMA, N. H, HAMEED, S, ABBAS, G, & HUSSAIN, M. T (2005). Synthesis of Some New Dihalophenyl- and Dihalobenzylisocoumarins and Their (dl)-3,4-Dihydroderivatives. Turkish Journal of Chemistry 29 (3): 321-326. https://doi.org/-
