Synthesis and Antimicrobial Evaluation of Some New 2-(2-(p-chlorophenyl) benzimidazol-1-yl methyl)-5-substituted amino-[1,3,4]-thiadiazoles

Authors

GÜLGÜN AYHAN KILCIGİL
CANAN KUŞ
NURTEN ALTANLAR
SÜHEYLA ÖZBEY

DOI

-

Abstract

Some 2-(2-(p-chlorophenyl)benzimidazol-1-ylmethyl)-5-substituted amino-[1,3,4]-thiadiazoles were synthesized and their in vitro antimicrobial activities were tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Candida krusei. Compounds 1b and 12b which possess remarkable activity against C. albicans and marginal activity against C. krusei were found to be the most active compounds in this series. Single crystal X-ray diffraction analysis was performed for compound 8b.

Keywords

Benzimidazoles, thiadiazoles, antimicrobial activity, X-ray

First Page

153

Last Page

162

Recommended Citation

KILCIGİL, GÜLGÜN AYHAN; KUŞ, CANAN; ALTANLAR, NURTEN; and ÖZBEY, SÜHEYLA (2005) "Synthesis and Antimicrobial Evaluation of Some New 2-(2-(p-chlorophenyl) benzimidazol-1-yl methyl)-5-substituted amino-[1,3,4]-thiadiazoles," Turkish Journal of Chemistry: Vol. 29: No. 2, Article 6. Available at: https://journals.tubitak.gov.tr/chem/vol29/iss2/6