A Concise Synthesis and the Antibacterial Activity of 5,6-Dimethoxynaphthalene-2-carboxylic Acid

Authors

SÜLEYMAN GÖKSU
METİN TANSU UĞUZ
HASAN ÖZDEMİR
HASAN SEÇEN

Abstract

5,6-Dimethoxynaphthalene-2-carboxylic acid was synthesized in 7 steps and with an overall yield of 46%. Bromination of 2-naphthol, and methylation with dimethyl sulfate followed by Friedel-Crafts acylation with AcCl gave 2-acetyl-5-bromo-6-methoxynaphthalene. 2-Acetyl-5-bromo-6-methoxynaphthalene was converted to 5-bromo-6- methoxynaphthalene-2-carboxylic acid by a haloform reaction. The esterification of the acid with methanol, methoxylation with NaOCH_3 in the presence of CuI and subsequent de-esterification with NaOH afforded 5,6-dimethoxynaphthalene-2-carboxylic acid. The 5-bromo-6-methoxynaphthalene-2-carboxylic acid and 5,6-dimethoxynaphthalene-2-carboxylic acid were found to have in vitro antibacterial activity against some pathogenic bacteria.

DOI

-

Keywords

Naphthalene-2-carboxylic acids, 2-naphthol, bromination, haloform, antibacterial activity

First Page

199

Last Page

205

Recommended Citation

GÖKSU, S, UĞUZ, M. T, ÖZDEMİR, H, & SEÇEN, H (2005). A Concise Synthesis and the Antibacterial Activity of 5,6-Dimethoxynaphthalene-2-carboxylic Acid. Turkish Journal of Chemistry 29 (2): 199-205. https://doi.org/-