Turkish Journal of Chemistry
Synthesis and Antimicrobial Activities of Some New Flavonyl Pro-drug Esters of Ampicillin
A new series of flavonyl pro-drug esters of ampicillin (Va-b) was prepared by condensing the appropriate bromomethyl flavone with ampicillin trihydrate potassium salt. Flavone derivatives and ampicillin both have good antibacterial activity. The synthesized compounds were tested for their antifungal and antibacterial activities in vitro. Both of the compounds were active against Candida krusei and Staphylococcus aureus.
Flavone derivatives, Ampicillin, Pro-drug ester, Antimicrobial activities
ÜNLÜSOY, MELTEM CEYLAN; ALTANLAR, NURTEN; and ERTAN, RAHMİYE (2005) "Synthesis and Antimicrobial Activities of Some New Flavonyl Pro-drug Esters of Ampicillin," Turkish Journal of Chemistry: Vol. 29: No. 2, Article 10. Available at: https://journals.tubitak.gov.tr/chem/vol29/iss2/10