Preparation, Spectroscopic Studies and Biological Activity of Mono-organotin(IV) Derivatives of Non-Steroidal Anti-inflammatory Drugs

Authors

AZRA JALAL
SAIRA SHAHZADI
KHADIJI SHAHID
SAQIB ALI
AMIN BADSHAH
MOHAMMAD MAZHAR
KHALID MOHAMMED KHAN

DOI

-

Abstract

A set of 14 mono-organotin(IV) derivatives of general formulae n-BuSnClL_2 and n-BuSnL_3, where `L' are various non-steroidal anti-inflammatory drugs (NSAIDs), were synthesized and structurally characterized by vibrational, ^1H, ^{13}C and ^{119}Sn spectroscopies and mass spectrometry to propose their structure. Biological activity data (antibacterial, antifungal and cytotoxicity) of the synthesized complexes were compared with the precursors to establish the significance of the complexes.

Keywords

Mono-organotin(IV) derivatives, non-steroidal anti-inflammatory drugs, biological activity.

First Page

629

Last Page

644

Recommended Citation

JALAL, AZRA; SHAHZADI, SAIRA; SHAHID, KHADIJI; ALI, SAQIB; BADSHAH, AMIN; MAZHAR, MOHAMMAD; and KHAN, KHALID MOHAMMED (2004) "Preparation, Spectroscopic Studies and Biological Activity of Mono-organotin(IV) Derivatives of Non-Steroidal Anti-inflammatory Drugs," Turkish Journal of Chemistry: Vol. 28: No. 5, Article 11. Available at: https://journals.tubitak.gov.tr/chem/vol28/iss5/11