Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]- 5-aminoalkyl/aryl-1,3,4-thiadiazole

Authors

TİJEN ÖNKOL
BİLGE ÇAKIR
M. FETHİ ŞAHİN
ENGİN YILDIRIM
KEVSER EROL

DOI

-

Abstract

Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and ^1H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.

Keywords

2-Oxobenzothiazoline, 1, 3, 4-thiadiazole, antinociceptive activity

First Page

461

Last Page

468

Recommended Citation

ÖNKOL, TİJEN; ÇAKIR, BİLGE; ŞAHİN, M. FETHİ; YILDIRIM, ENGİN; and EROL, KEVSER (2004) "Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]- 5-aminoalkyl/aryl-1,3,4-thiadiazole," Turkish Journal of Chemistry: Vol. 28: No. 4, Article 8. Available at: https://journals.tubitak.gov.tr/chem/vol28/iss4/8