Turkish Journal of Chemistry
Abstract
Some new antimicrobial active N-(2-hydroxy-4-nitrophenyl)- p-substituted benzamide and phenylacetamide analogues (I-II) were prepared by 2-step procedures from the corresponding carboxylic acids as possible metabolites of benzoxazoles. Their antimicrobial activities were tested against 3 Gram-positive and 2 Gram-negative bacteria with the fungus Candida albicans and were also compared with several control drugs. The compounds Ia, Id, IIa, and IIe were active at a MIC value of 12.5 \mu g/mL against the Gram-positive microorganism Bacillus subtilis. Most of the compounds exhibited antifungal activity at a MIC value of 12.5 \mu g/mL against C. albicans. On the other hand, the antimicrobial activity of some amide derivatives (Ia, Id, IIa-c) was also compared with their cyclic analogues, benzoxazole derivatives (III-IV). The compound Id significantly possessed 2 or 3 dilutions better antimicrobial activity than its heterocyclic derivative, 2-(p-t-butylphenyl)-5-nitrobenzoxazole, IIId, against Staphylococcus aureus, Streptococcus faecalis, Klebsiella pneumonia, and Escherichia coli.
DOI
-
Keywords
Antimicrobial activity, benzamide, benzoxazole, phenylacetamide
First Page
441
Last Page
450
Recommended Citation
ÖREN, İ. Y, ŞENER, E. A, ERTAŞ, C, ARPACI, Ö. T, YALÇIN, İ, & ALTANLAR, N (2004). Synthesis and Microbiological Activity of Some Substituted N-(2-hydroxy-4-nitrophenyl)benzamides and Phenylacetamides as Possible Metabolites of Antimicrobial Active Benzoxazoles. Turkish Journal of Chemistry 28 (4): 441-450. https://doi.org/-
