Turkish Journal of Chemistry
Abstract
The title compounds were efficiently synthesised starting from aryl methyl ketones in 3 steps. Knoevenagel condensation of aryl methyl ketones with malononitrile gave the corresponding crotonitriles (5a-f). Methyl groups of the crotonitriles (5a-f) were then efficiently brominated by refluxing and lightening the reaction media to give bromocrotonitriles (6a-f). The bromocrotonitriles (6a-f) were finally cyclised by treatment with NaSH to give the title compounds.
DOI
-
Keywords
Aminothiophenes, bromocrotonitriles, substituted aminothiophenes
First Page
395
Last Page
404
Recommended Citation
TÜMER, F, EKİNCİ, D, ZİLBEYAZ, K, & DEMİR, Ü (2004). An Efficient Synthesis of Substituted 4-Aryl-3-Cyano-2-Amino Thiophenes by a Stepwise Gewald Reaction. Turkish Journal of Chemistry 28 (4): 395-404. https://doi.org/-
